| The Athletic | online newspaper, podcast network, business, sports journalism | January 2016 |
| TopCoder | business, enterprise | 2001 |
| Twilio | website, business, company, public company | 2008 |
| Udemy | website, education company | 2010 |
| Union Iron Works | business | 1849 |
| Viz Media, LLC | publishing house, business, company | 1984 |
| Wells Fargo | global systemically important bank, bank, business, financial institution, enterprise, public company | March 18, 1852 |
| Western Pacific Railroad | business, transport company | 1916 |
| Wish.com | online marketplace, business, mobile app, enterprise | 2010 |
| Yelp | review site, social networking service, business, enterprise, public company | 2004 |
| Yerba Buena Center for the Arts | nonprofit organization, museum, movie theater, built structure | — |
| Zendesk | software company, technology company, business, public company | 2007 |
| Zynga | video game developer, public company | 2007 |