| Auburn Automobile | business | Auburn | 1900 |
| AutoZone | car parts shop chain, public company | Memphis | 1979 |
| Baker Motor Vehicle | business, automobile manufacturer | Cleveland | 1899 |
| Bendix Corporation | business | — | 1924 |
| BorgWarner | business, enterprise, public company | Auburn Hills | 1880 |
| Buick | car brand, division, automobile manufacturer, public company | Detroit | December 1899 |
| Carroll Shelby International | automobile manufacturer | Enterprise | August 17, 1962 |
| Cartercar | business, automobile manufacturer | Pontiac | 1905 |
| Coda Automotive | business, automobile manufacturer | Los Angeles | 2009 |
| Crosley | business, automobile manufacturer | Cincinnati | 1937 |
| DeLorean Motor Company | automobile manufacturer | Detroit | October 24, 1975 |
| Detroit Diesel | automobile manufacturer | Detroit | 1938 |
| Dodge | car brand, business, enterprise, automobile manufacturer | Dodge Building | December 14, 1900 |
| Durant Motors | automobile manufacturer | Lansing | 1921 |
| Dynetics | business | Huntsville | 1974 |
| Eagle | car brand, automobile manufacturer | — | 1987 |
| Freightliner Trucks | truck manufacturer, trademark | Portland | 1939 |
| Harley-Davidson | motorcycle manufacturer | Milwaukee | 1903 |
| Hennessey Performance Engineering | business, automobile manufacturer | Houston | 1992 |
| Henry Ford Company | business, automobile manufacturer | Detroit | 1901 |
| Intermeccanica | automobile manufacturer | Vancouver | 1959 |
| Jeep | car brand, business, enterprise, automobile manufacturer | Toledo | 1941 |
| Kaiser Motors | automobile manufacturer | Ypsilanti | 1945 |
| LaSalle | automobile manufacturer | Detroit | 1927 |
| Mack Trucks | business, enterprise | Allentown, Greensboro | 1900 |
| Marmon Motor Car Company | business, automobile manufacturer | Indianapolis | 1902 |
| Mercer Automobile Company | business | New Britain | 1909 |
| Oshkosh Corporation | business, enterprise, public company | Oshkosh | 1917 |
| PhoenixEV | business, automobile manufacturer | Ontario, California | 2002 |
| Polaris | motorcycle manufacturer, enterprise, automobile manufacturer, public company | Medina | 1954 |
| Pope Manufacturing Company | automobile manufacturer | Hartford | 1876 |
| Ram Trucks | car brand, division, automobile manufacturer | Auburn Hills | 2010 |
| SSC North America | business, enterprise, automobile manufacturer | West Richland | 1999 |
| Stanley Motor Carriage Company | automobile manufacturer | Newton | 1902 |
| Sterling Trucks | truck manufacturer, commercial vehicle manufacturer | Redford | 1997 |
| Textron | conglomerate, public company | Rhode Island, Providence | 1923 |
| Vector Motors | business, automobile manufacturer | — | 1978 |
| White Motor Company | business, automobile manufacturer | Cleveland | 1902 |
| Winnebago Industries | business, enterprise, public company | Eden Prairie | February 12, 1958 |
| Winton Motor Carriage Company | business, automobile manufacturer | Cleveland | 1897 |
| Workhorse Group | original equipment manufacturer, business, public company | Cincinnati, Sharonville | 1998 |