| Deep Space Industries | Mountain View | January 22, 2013 |
| Del Monte Foods | San Francisco | 1886 |
| Dell EMC | Hopkinton | August 1979 |
| Dell Technologies | Round Rock | September 7, 2016 |
| Democratic National Committee | Washington, D.C. | 1848 |
| Diamond Multimedia | Los Angeles | 1982 |
| Dickies | Fort Worth | 1918 |
| Diebold Nixdorf | North Canton | 1859 |
| Digital Photography Review | — | 1998 |
| DigitalGlobe | Westminster | 1992 |
| Diners Club International | Riverwoods | 1950 |
| Discovery, Inc. | New York City | 1982 |
| Dish | Meridian | 1996 |
| Disney Cruise Line | Celebration | 1995 |
| Disney Music Group | Burbank | 1998 |
| Disney Television Animation | Glendale | December 5, 1984 |
| Dodge | Dodge Building | December 14, 1900 |
| Dolby | San Francisco | 1965 |
| Dollar Tree | Chesapeake | 1986 |
| DoubleTree by Hilton | McLean | 1969 |
| Dow Chemical Company | Midland | 1897 |
| Dr Pepper Snapple Group | Plano | May 7, 2008 |
| Draken International | Lakeland | January 2012 |
| Dremel | Racine | 1932 |
| Drum Workshop | Oxnard | 1972 |
| Dunkin' Brands | Canton | 1950 |
| DXC Technology | Tysons | April 3, 2017 |
| DYMO Corporation | Berkeley | 1958 |
| Dynetics | Huntsville | 1974 |
| E-mu Systems | Scotts Valley | 1971 |
| E-Trade | New York City | 1982 |
| E-ZPass | Wilmington | 1987 |
| EA Sports | Burnaby | 1991 |
| Eaton Corporation | Cleveland | 1911 |
| EBSCO Information Services | Birmingham | 1943 |
| Eckert–Mauchly Computer Corporation | Philadelphia | 1948 |
| Eckō Unltd. | East Brunswick | 1993 |
| Edelman | New York City | 1952 |
| Edison Manufacturing Company | New York | 1889 |
| Edmodo | San Mateo | September 1, 2008 |
| Einstein Bros. Bagels | Lakewood | 1995 |
| Emerson Electric | St. Louis | September 24, 1890 |
| EMG, Inc. | Santa Rosa | 1976 |
| Encyclopædia Britannica Inc. | Chicago | 1768 |
| Energizer Holdings, Inc. | St. Louis | 2000 |
| Ensoniq | Malvern | 1982 |
| Enterprise Products | Houston | 1968 |
| EnterpriseDB | Bedford | March 2004 |