| Trimark Pictures | Santa Monica | 1985 |
| Trimble | Westminster | 1978 |
| Tripadvisor | Needham | February 14, 2000 |
| Trump Steaks | New York City | May 8, 2007 |
| TRW Inc. | Euclid | 1901 |
| Turner Broadcasting System | CNN Center | 1970 |
| Turner Construction | New York City | 1902 |
| Turner Entertainment | United States | August 4, 1986 |
| Turtle Beach Systems | Valhalla | 1975 |
| Twilio | San Francisco | 2008 |
| Tyson Foods | Springdale | 1935 |
| U.S. Bancorp | Minneapolis | 1850 |
| U.S. Steel | Pittsburgh | 2001 |
| Undead Labs | Seattle | November 23, 2009 |
| Unimation | — | 1962 |
| Union Carbide | Danbury | 1957 |
| Union Iron Works | San Francisco | 1849 |
| United Airlines Holdings | Chicago | December 30, 1968 |
| United Fruit Company | New Orleans | 1899 |
| United Parcel Service | Sandy Springs | August 28, 1907 |
| United Press International | Washington, D.C. | 1907 |
| United Space Alliance | Houston | August 1995 |
| United States Playing Card Company | Erlanger | 1867 |
| United States Rubber Company | Naugatuck | 1892 |
| United States Wrestling Association | Memphis | 1989 |
| United Technologies Corporation | Hartford | 1929 |
| UnitedHealth Group | Minnetonka | 1977 |
| US Foods | Rosemont | August 1, 1989 |
| USA Today Co. | Tysons, New York City | October 6, 1906 |
| USAA | — | 1922 |
| Valero Energy | — | 1980 |
| Vector Motors | — | 1978 |
| Venmo | New York City | 2009 |
| Verbatim | Charlotte | April 28, 1969 |
| VeriFone | San Jose, Coral Springs | 1981 |
| Vertex Pharmaceuticals | Boston | 1989 |
| Vertiv | Westerville | 1965 |
| Viagogo | London | 2006 |
| Vic Firth Company | Boston | 1963 |
| Victoria's Secret Fashion Show | — | 1995 |
| Victory Motorcycles | Minneapolis | 1997 |
| Vincent Bach Corporation | Mount Vernon | 1918 |
| Visa Inc. | Mission Rock | 1958 |
| Viz Media, LLC | San Francisco | 1984 |
| Wall Street English | Baltimore | 1972 |
| Walmart | Bentonville | October 31, 1969 |
| Walt Disney Imagineering | Glendale | 1952 |
| Waltham Watch Company | Waltham, Amsterdam | 1850 |