| Raytheon | Waltham | July 7, 1922 |
| Razer Inc. | George Town, Singapore, Carlsbad, Irvine, San Francisco | 1998 |
| Realty Income Corporation | San Diego | 1969 |
| Regeneron Pharmaceuticals | Eastview | 1988 |
| Regions Financial Corporation | Birmingham | July 13, 1971 |
| Roblox Corporation | San Mateo | 2004 |
| Rockwell Collins | Cedar Rapids | 1933 |
| Rockwell International | United States | February 1973 |
| Roku, Inc. | Los Gatos | October 2002 |
| Royal Caribbean Group | Miami | 1997 |
| Ryder | Coral Gables | 1933 |
| Sanmina Corporation | San Jose | 1980 |
| Scholastic Corporation | New York City, Scholastic Building | 1920 |
| Seagate Technology | Cupertino | 1979 |
| Sears | Hoffman Estates | 1892 |
| Shutterstock | New York City, Empire State Building | 2003 |
| Silvergate Capital | La Jolla | 1988 |
| Sinclair Broadcast Group | Hunt Valley, Cockeysville, Union Valley | 1971 |
| SLB | Houston | 1926 |
| Snap-on | Kenosha | 1920 |
| Sonos | Santa Barbara | 2002 |
| SoundHound | Santa Clara | September 2005 |
| Southern Company | Atlanta | 1945 |
| SpaceX | Starbase | March 14, 2002 |
| Spectrum Brands | Middleton | 1906 |
| Sprint Corporation | Overland Park | 1899 |
| Squarespace | New York City | 2003 |
| Stanley Black & Decker | New Britain | 1843 |
| Staples Inc. | Framingham | 1986 |
| Starwood | White Plains | 1930 |
| State Street Corporation | Boston | 1792 |
| Steelcase | Grand Rapids | 1912 |
| Stepan Company | Northfield | 1932 |
| Strategy | Tysons | 1989 |
| Sun Microsystems | Santa Clara | February 24, 1982 |
| SurveyMonkey | San Mateo | 1999 |
| Synopsys | Mountain View | 1986 |
| Sysco | Houston | 1969 |
| T. Rowe Price | Baltimore | 1937 |
| Target Corporation | Minneapolis | June 24, 1902 |
| Teradyne | North Reading | 1960 |
| Textron | Rhode Island, Providence | 1923 |
| The Cheesecake Factory | Calabasas | 1978 |
| The Cigna Group | Bloomfield | 1982 |
| The Gillette Company | — | September 28, 1901 |
| The McClatchy Company | Sacramento | 1857 |
| The Travelers Companies | New York City | 1853 |
| THQ | Agoura Hills, California | 1990 |