| Tiffany & Co. | New York City | 1837 |
| TiVo Corporation | Santa Clara, San Jose | 1983 |
| TJX Companies | Framingham | 1956 |
| Trident Microsystems | Santa Clara | 1987 |
| Trimble | Westminster | 1978 |
| Tripadvisor | Needham | February 14, 2000 |
| Turtle Beach Systems | Valhalla | 1975 |
| Twilio | San Francisco | 2008 |
| Tyson Foods | Springdale | 1935 |
| U.S. Bancorp | Minneapolis | 1850 |
| U.S. Steel | Pittsburgh | 2001 |
| Union Pacific Railroad | Omaha | 1862 |
| United Airlines | Chicago, Willis Tower | April 6, 1926 |
| United Airlines Holdings | Chicago | December 30, 1968 |
| United Parcel Service | Sandy Springs | August 28, 1907 |
| United Technologies Corporation | Hartford | 1929 |
| UnitedHealth Group | Minnetonka | 1977 |
| Universal Music Group | Broadway, New York, Santa Monica, California | September 1934 |
| US Foods | Rosemont | August 1, 1989 |
| Valero Energy | — | 1980 |
| Valvoline | Lexington | September 6, 1866 |
| VeriFone | San Jose, Coral Springs | 1981 |
| Vertex Pharmaceuticals | Boston | 1989 |
| Vertiv | Westerville | 1965 |
| Viatris | Pittsburgh | November 2020 |
| Visa Inc. | Mission Rock | 1958 |
| Walgreens | Deerfield | 1901 |
| Walmart | Bentonville | October 31, 1969 |
| Warner Bros. Discovery | New York City | April 8, 2022 |
| Warner Music Group | Paramount Plaza, New York City | April 6, 1958 |
| WarnerMedia | Delaware, New York City | 2016 |
| Waste Management, Inc | Houston | 1968 |
| Wells Fargo | San Francisco | March 18, 1852 |
| Western Digital | San Jose | April 23, 1970 |
| WeWork | Manhattan, New York | 2010 |
| Weyerhaeuser | Seattle, Federal Way | 1900 |
| Wiley | Hoboken | 1807 |
| Wilhelmina Models | New York City | 1967 |
| Wingstop | Dallas | 1994 |
| Winnebago Industries | Eden Prairie | February 12, 1958 |
| WME Group | Beverly Hills | 1898 |
| Workhorse Group | Cincinnati, Sharonville | 1998 |
| WSP Global | Montreal | 1959 |
| WW International | New York City | 1963 |
| WWE | Stamford | 1952 |
| Wynn Resorts | Las Vegas | 2002 |
| XPO, Inc. | Greenwich | 1987 |
| Yelp | 140 New Montgomery, San Francisco | 2004 |