| Yacht Club Games | video game developer | Valencia | 2011 |
| Yahoo Inc. | division, business, new media, company | Sunnyvale, New York City | 2006 |
| Yale Law School | law school, academic publisher | New Haven | 1824 |
| Yale School of Drama | drama school | — | 1924 |
| Yale University Press | book publisher, university press | New Haven | 1908 |
| Yelp | review site, social networking service, business, enterprise, public company | 140 New Montgomery, San Francisco | 2004 |
| Yerba Buena Center for the Arts | nonprofit organization, museum, movie theater, built structure | San Francisco | — |
| Yeshiva University | private not-for-profit educational institution, private university | New York City | 1886 |
| Young & Rubicam | advertising agency | Philadelphia, New York City | 1923 |
| Yum! Brands | corporation, group of companies, public company | Louisville | 1997 |