| Valero Energy | business, gas station chain, enterprise, public company | — | 1980 |
| Valvoline | public company | Lexington | September 6, 1866 |
| Vdara | skyscraper, hotel, resort | — | 2009 |
| Vector Motors | business, automobile manufacturer | — | 1978 |
| Venmo | online service, website, business | New York City | 2009 |
| Verbatim | business, enterprise | Charlotte | April 28, 1969 |
| VeriFone | business, public company | San Jose, Coral Springs | 1981 |
| Verso Books | publishing house | New York City, London | 1970 |
| Vertex Pharmaceuticals | pharmaceutical company, organization, business, public company | Boston | 1989 |
| Vertical | film distributor | California | 2012 |
| Vertiv | multinational corporation, business, enterprise, public company | Westerville | 1965 |
| Viagogo | business, ticket sales service, ticket reseller | London | 2006 |
| Viatris | multinational corporation, pharmaceutical company, public company | Pittsburgh | November 2020 |
| Vic Firth Company | business, musical instrument manufacturing company | Boston | 1963 |
| Victoria's Secret Fashion Show | fashion show, recurring event, business | — | 1995 |
| Victory Motorcycles | business | Minneapolis | 1997 |
| Viking Press | book publisher, publishing house, imprint | New York City | 1925 |
| Villanova University | private not-for-profit educational institution, open-access publisher, Catholic university, private university | — | 1842 |
| Vincent Bach Corporation | company-manufacturer of music accessories, business, musical instrument manufacturing company | Mount Vernon | 1918 |
| Virgin America | airline | Burlingame | 2004 |
| Virgin Orbit | launch service provider | Long Beach, California | March 2, 2017 |
| Virginia Commonwealth University | public educational institution of the United States, public research university | — | 1968 |
| Virginia Tech | public educational institution of the United States, United States senior military college, university, land-grant university | — | 1872 |
| Visa Inc. | multinational corporation, business, card association, enterprise, public company | Mission Rock | 1958 |
| Viz Media, LLC | publishing house, business, company | San Francisco | 1984 |
| VLF Automotive | automobile manufacturer | Rochester | 2015 |
| Voat | dot-com company, social networking service, aggregator, social news website | — | 2014 |
| Volition | video game developer | Champaign | November 1996 |