| F5, Inc. | software company, public company | Seattle | 1996 |
| Fairchild | aerospace manufacturer | — | 1925 |
| Fairfax County Public Schools | school division of Virginia | — | 1870 |
| Fairleigh Dickinson University | nonprofit organization, private not-for-profit educational institution, university | — | 1942 |
| Fairmont Hotels & Resorts | hotel brand, hotel chain, business | Toronto | 1907 |
| Fandango | online film database, website, business | Los Angeles | 2000 |
| Fantagraphics Books | comics publishing company, book publisher | Seattle | 1976 |
| Fantasy Flight Games | tabletop role-playing game publisher, board game publishing company, business | Roseville | 1995 |
| Farmers Insurance Group | insurance company, business | Wilshire Boulevard, Los Angeles | 1928 |
| Farrar, Straus and Giroux | publishing house | New York City | 1946 |
| Fastenal | business, enterprise, public company | Winona | 1967 |
| Fatburger | restaurant chain | Santa Monica, Los Angeles | 1952 |
| Feastables | business, company | Chicago | April 2021 |
| Federal Reserve Bank of Atlanta | organization, Federal Reserve Bank | Atlanta | May 18, 1914 |
| Federal Reserve Bank of Cleveland | organization, Federal Reserve Bank | Federal Reserve Bank Building | May 18, 1914 |
| Federal Reserve Bank of Dallas | organization, Federal Reserve Bank | Dallas | 1914 |
| Federal Reserve Bank of Minneapolis | publishing house, organization, Federal Reserve Bank | Minneapolis | 1914 |
| Federal Reserve Bank of New York | Federal Reserve Bank | New York City | 1914 |
| FedEx Office | business, retail chain | Dallas | 1970 |
| FEI Company | business, enterprise, public company | Hillsboro | 1971 |
| Fender Musical Instruments Corporation | business, musical instrument manufacturing company | Nabari Station | 1946 |
| Ferris State University | public educational institution of the United States, university | Big Rapids | 1884 |
| Fidelity National Information Services | business, public company | — | February 1, 2006 |
| Film Roman | animation studio, film production company | Burbank | October 26, 1984 |
| Firehouse Subs | business | — | 1994 |
| First Data | business | Atlanta | 1969 |
| First Look Media | news agency | New York City | 2013 |
| First Solar | business, enterprise, public company | Tempe | 1999 |
| Fiserv | business, enterprise, public company | Brookfield | 1984 |
| Fisher-Price | brand, business, subsidiary company | New York | June 19, 1930 |
| Florida A&M University | historically black college or university, public educational institution of the United States, school, university, land-grant university | — | 1887 |
| Florida Atlantic University | public educational institution of the United States, university | Boca Raton | 1961 |
| Florida Gulf Coast University | public educational institution of the United States, university, census-designated place in the United States | Fort Myers | 1991 |
| Florida State University | public educational institution of the United States, public university | — | 1851 |
| Florsheim Shoes | business | Glendale | 1892 |
| Fluor Corporation | business, public company | Irving | 1890 |
| Flying Tiger Line | airline | Los Angeles | 1945 |
| FMC Corporation | business, enterprise, public company | BNY Mellon Center | 1883 |
| FMC Technologies | business, public company | Houston | 2000 |
| Folger Shakespeare Library | Shakespeariana, library, art collection, library building | — | 1932 |
| Fontainebleau Miami Beach | convention center, hotel, landmark, resort | Miami Beach | 1954 |
| Foot Locker | business, enterprise, shoe store chain, public company | New York City | 1974 |
| Ford Aerospace | business | Milpitas | 1956 |
| Forrester | business, public company | Cambridge | 1983 |
| Fortinet | business, public company | Sunnyvale | 2000 |
| Fortress Investment Group | public company | 1345 Avenue of the Americas | 1998 |
| Four Seasons Hotel Miami | skyscraper, hotel | — | 2003 |
| Fox Broadcasting Company | television production company, television network | 1211 Avenue of the Americas | October 9, 1986 |
| Fox Film Corporation | production company, film production company, film studio | Hollywood | 1915 |
| Fox Kids | television production company, television channel, specialty channel | United States | September 8, 1990 |
| Fox Sports Networks | television production company, television station, specialty channel | Los Angeles | 1996 |
| Fox Television Stations | business, subsidiary company | New York City | 1986 |
| Freightliner Trucks | truck manufacturer, trademark | Portland | 1939 |
| Frigidaire | business, subsidiary company, enterprise | Charlotte | 1918 |
| Frontier Airlines | organization, airline, business | Denver | 1994 |
| Fry's Electronics | business, enterprise, electronics store chain | San Jose | 1985 |
| Fulbright Scholarship | scholarship, government program, educational institution | — | 1946 |
| Furman University | liberal arts college, private not-for-profit educational institution | Greenville | 1826 |
| Fusion-io | business, enterprise | Cottonwood Heights | 2006 |
| FX | television production company, cable channel | Texas, New York City, Pico Boulevard | June 1, 1994 |