| Ritual Entertainment | video game developer | Dallas | 1996 |
| Roblox Corporation | video game developer, business, public company | San Mateo | 2004 |
| Rockhurst University | private not-for-profit educational institution, university | Clayton | 1910 |
| Rockstar Games | video game publisher | New York City | December 1998 |
| Rockstar New England | video game developer | Andover | 1999 |
| Rockwell Collins | defense contractor, business, public company, aerospace manufacturer | Cedar Rapids | 1933 |
| Rockwell International | conglomerate, public company | United States | February 1973 |
| Rogue | film production company | Universal City | 1997 |
| Roku, Inc. | business, enterprise, public company | Los Gatos | October 2002 |
| Rooster Teeth | YouTube channel, film production company | Austin, Los Angeles, Flower Mound | April 1, 2003 |
| Rowan University | public educational institution of the United States, public university | Glassboro | 1923 |
| Rowman & Littlefield | book publisher, publishing house | Lanham | 1949 |
| Roxy Theatre | nightclub, music venue | — | September 23, 1973 |
| Royal Caribbean Group | business, enterprise, public company | Miami | 1997 |
| Royal Hawaiian Hotel | hotel, hotel building | — | 1927 |
| Rutgers University Press | university press | New Brunswick | 1936 |
| Rutherford B. Hayes Presidential Center | library | — | 1912 |
| Ryder | business, retail chain, public company | Coral Gables | 1933 |
| Saber Interactive | video game developer | Fort Lauderdale, Minsk, Sundsvall, Porto, Millburn, Community of Madrid, Saint Petersburg, Florida | 2001 |
| Saint Anselm College | private not-for-profit educational institution, liberal arts college in the United States | Manchester | 1889 |
| Saint Joseph Higher Secondary School | college | — | 1954 |
| Saint Joseph's University | private not-for-profit educational institution, university | — | 1851 |
| San Francisco Art Institute | private not-for-profit educational institution, art academy, private university | San Francisco | 1961 |
| Sanmina Corporation | business, public company | San Jose | 1980 |
| Santa Barbara City College | community college, public educational institution of the United States, school | — | 1909 |
| Santa Clara University | private not-for-profit educational institution, university | Santa Clara | 1851 |
| Santa Monica College | community college, college, public educational institution of the United States | Santa Monica | 1929 |
| Santa Monica Studio | video game developer | Playa Vista | 1999 |
| Sara Lee Corporation | business, enterprise | Downers Grove | 1939 |
| Saucony | business, subsidiary company | Lexington | 1898 |
| Sbarro | fast food restaurant chain, pizzeria chain, company | Huntington | 1956 |
| Scaled Composites | aerospace manufacturer | Mojave | 1982 |
| Schneider's Bakery | television production company | Los Angeles | June 6, 1996 |
| Scholastic Corporation | media distributor, book publisher, business, education company, public company | New York City, Scholastic Building | 1920 |
| Schomburg Center for Research in Black Culture | library branch, creative residency, research library, public library, library building | — | 1925 |
| School of Visual Arts | private for-profit educational institution, art academy, university | New York City | 1947 |
| Schweizer Aircraft Corporation | former entity, organization, business | Horseheads, New York City | 1939 |
| Scribd | online service, organization, business | San Francisco | March 2006 |
| Scripps Institution of Oceanography | centre for marine biology, educational institution, research institute | — | 1903 |
| SDI Media Group | film organization, business | Culver City | 1965 |
| Seabourn Cruise Line | business, cruise line | Seattle, Miami | 1986 |
| Seagate Technology | business, enterprise, public company | Cupertino | 1979 |
| Sean Cody | pornography website, pornographic film studio | United States | 2001 |
| Searchlight Pictures | television production company, film production company, film studio, subsidiary company | Los Angeles | 1994 |
| Sears | business, public company | Hoffman Estates | 1892 |
| Seattle Computer Products | business | Seattle | 1979 |
| Seattle University | private not-for-profit educational institution, Catholic university | Seattle | 1891 |
| Seeburg Corporation | business | Chicago | 1902 |