| Disney's Hollywood Studios | theme park | — | May 1, 1989 |
| Disney's Paradise Pier Hotel | hotel | — | May 25, 1984 |
| DLA Piper | law firm | New York City | 2005 |
| Dodge | car brand, business, enterprise, automobile manufacturer | Dodge Building | December 14, 1900 |
| Dolby | business, enterprise, public company | San Francisco | 1965 |
| Dollar Tree | business, retail chain, public company | Chesapeake | 1986 |
| Dominican University | private not-for-profit educational institution, university, Catholic university | — | 1901 |
| DoubleTree by Hilton | hotel brand, hotel chain, business, enterprise | McLean | 1969 |
| Dow Chemical Company | organization, business, enterprise, public company | Midland | 1897 |
| Dr Pepper Snapple Group | business, public company | Plano | May 7, 2008 |
| Drag City | independent record label | Chicago | 1990 |
| Drake University | private not-for-profit educational institution, private university | — | 1881 |
| Draken International | business | Lakeland | January 2012 |
| DreamWorks | film production company, film distributor | Universal City | October 12, 1994 |
| DreamWorks Animation | animation studio, film production company, film studio, public company | Glendale | 1994 |
| Dremel | trademark, business | Racine | 1932 |
| Drew University | botanical garden, private not-for-profit educational institution, university | — | 1867 |
| Drum Workshop | business, musical instrument manufacturing company, enterprise | Oxnard | 1972 |
| Dumbarton Oaks | research library, mansion, research institute, museum, academic publisher | — | 1940 |
| Dunkin' Brands | business, enterprise, public company | Canton | 1950 |
| Duquesne University | private not-for-profit educational institution, Catholic university | — | 1878 |
| Durant Motors | automobile manufacturer | Lansing | 1921 |
| DXC Technology | business, enterprise, public company | Tysons | April 3, 2017 |
| DYMO Corporation | business | Berkeley | 1958 |
| Dynetics | business | Huntsville | 1974 |
| E-mu Systems | business, musical instrument manufacturing company | Scotts Valley | 1971 |
| E-Trade | business, enterprise, public company | New York City | 1982 |
| E-ZPass | business | Wilmington | 1987 |
| EA Orlando | video game developer | Orlando | 1994 |
| EA Sports | business | Burnaby | 1991 |
| Eagle | car brand, automobile manufacturer | — | 1987 |
| Eastern Illinois University | public educational institution of the United States, school of pedagogy, public university | — | 1895 |
| Eastern Oregon University | public educational institution of the United States, public university | — | 1929 |
| Eastern Washington University | public educational institution of the United States, university | — | 1882 |
| Eastman School of Music | conservatory | — | 1921 |
| Eaton Corporation | business, enterprise, public company | Cleveland | 1911 |
| EBSCO Information Services | business | Birmingham | 1943 |
| Eckert–Mauchly Computer Corporation | business | Philadelphia | 1948 |
| Eckō Unltd. | business, subsidiary company, brick and mortar | East Brunswick | 1993 |
| Econometric Society | open-access publisher, scientific society, learned society | — | December 29, 1930 |
| Edelman | public relations agency, consulting company, business | New York City | 1952 |
| Edison Manufacturing Company | film production company, business | New York | 1889 |
| Edison Studios | film production company, film studio | United States | 1882 |
| Edmodo | skill, website, business | San Mateo | September 1, 2008 |
| Einstein Bros. Bagels | restaurant chain, business, public company | Lakewood | 1995 |
| El Capitan Theatre | movie theater, movie palace | — | 1926 |
| Elegant Angel | pornographic film studio | Los Angeles | 1990 |
| Elon University | university | — | 1889 |