| Holiday Inn Express | hotel chain, brand, business | — | 1991 |
| Holland America Line | business, enterprise, cruise line | Seattle | 1873 |
| Hollywood Pantages Theatre | theatre building, movie theater, music venue | — | 1930 |
| Hollywood Roosevelt Hotel | hotel | — | 1927 |
| Honeywell | business, enterprise, public company | Charlotte | April 23, 1885 |
| Hormel | business, enterprise, company, public company | Austin | 1891 |
| Hot Topic | retail chain | City of Industry | 1988 |
| Hotel del Coronado | hotel | New York City | — |
| Houghton Mifflin Harcourt | book publisher, publishing house, public company | Boston | 1880 |
| Houlihan Lokey | investment bank | Los Angeles | 1972 |
| House of Blues | restaurant chain, business, chain | Los Angeles | November 26, 1992 |
| Howard University | historically black college or university, private not-for-profit educational institution, school, private university | Washington, D.C. | March 2, 1867 |
| HRG Group | business, public company | Rochester | 1953 |
| Hudson Theatre | Broadway theatre, theatre building, movie theater | — | October 19, 1903 |
| Hulu | online film database, website, business, video streaming service | Santa Monica | March 2007 |
| Human Head Studios | video game developer | Madison | October 1997 |
| Humble Bundle, Inc. | video game publisher, digital book and audiobook distribution platform, digital distribution platform | San Francisco | March 1, 2010 |
| Hurley International | business, subsidiary company | Costa Mesa | 1998 |
| Hy-Vee | supermarket chain, business | West Des Moines | 1930 |
| IBM Cloud Video | website, business, online video platform, online community | San Francisco | 2007 |
| Icahn School of Medicine at Mount Sinai | private not-for-profit educational institution, medical school | — | 1963 |
| Idaho State University | public educational institution of the United States, public research university | — | 1901 |
| IESE Business School | business school | — | 1958 |
| IFixit | wiki, business | San Luis Obispo | 2003 |
| IGN | online newspaper, online film database, business, video game news website | San Francisco | September 29, 1996 |
| IHeartRadio | dot-com company, internet radio, podcast directory | 32 Avenue of the Americas | — |
| IIT Institute of Design | graduate school, design school, higher education institution, academic institution | — | 1937 |
| Illinois Institute of Technology | private not-for-profit educational institution, university | Chicago | 1940 |
| Illinois Tool Works | business, public company | Glenview | 1912 |
| ImageShack | website, business | Los Gatos | November 2003 |
| Imagic | video game publisher, video game developer | Los Gatos | 1981 |
| Imagine Entertainment | television production company, film production company | Beverly Hills | November 1985 |
| IMG | business | New York City | 1960 |
| IMG Models | modeling agency, division | New York | 1987 |
| Imgur | image hosting service, website, business | San Francisco | 2009 |
| Impossible Foods | business | Redwood City | 2011 |
| In-N-Out Burger | fast food restaurant chain | Irvine | 1948 |
| Incognito Entertainment | video game developer | Salt Lake City | May 1999 |
| Incyte | business, enterprise, public company | Wilmington | 2001 |
| Indeed | review site, search engine, business, employment website | Austin | November 2004 |
| Independent Moving Pictures | film studio, organization | New York City | 1909 |
| Indiana State University | public educational institution of the United States, public university | Terre Haute | 1865 |
| Indiana University Bloomington | public educational institution of the United States, public research university | Bloomington | 1820 |
| Indiana University of Pennsylvania | public educational institution of the United States, university | — | 1875 |
| Indiana University Press | open-access publisher, university press | Bloomington | 1950 |
| Indiana University – Purdue University Indianapolis | public educational institution of the United States, university, open-access publisher | Indianapolis | 1969 |
| InFocus | business | Tigard | 1986 |
| Infor Global Solutions | software company, business | New York City | 2002 |