| University of New Mexico | public educational institution of the United States, open-access publisher, public research university | Albuquerque | 1889 |
| University of North Carolina | state university system, state agency of North Carolina, educational institution | Chapel Hill | 1789 |
| University of North Carolina at Asheville | liberal arts college, public educational institution of the United States | Asheville | 1927 |
| University of North Carolina at Chapel Hill | public educational institution of the United States, public research university | — | December 11, 1789 |
| University of North Carolina Press | nonprofit organization, open-access publisher, university press | Chapel Hill | 1922 |
| University of North Dakota | research university, public educational institution of the United States, public university | — | 1883 |
| University of North Florida | public educational institution of the United States, university | — | 1969 |
| University of Notre Dame | private not-for-profit educational institution, open-access publisher, Catholic university, private university, academic publisher | — | November 26, 1842 |
| University of Oregon | research university, public educational institution of the United States, public university | Eugene | 1876 |
| University of Pennsylvania | colonial colleges, research university, private not-for-profit educational institution, private university | Philadelphia | November 14, 1740 |
| University of Puerto Rico | public university | — | 1903 |
| University of Rhode Island | research university, public educational institution of the United States, open-access publisher, land-grant university, public university | Kingston | 1892 |
| University of Saint Joseph | private not-for-profit educational institution, university | — | 1932 |
| University of San Diego | private not-for-profit educational institution, private university | San Diego | 1949 |
| University of South Carolina | research university, public educational institution of the United States, public university | — | 1801 |
| University of Tampa | private not-for-profit educational institution, university | — | 1931 |
| University of Tennessee | neighborhood, research university, public educational institution of the United States, university, land-grant university, sun grant institution, public university | Knoxville | 1794 |
| University of Tennessee at Chattanooga | public educational institution of the United States, public university | — | 1886 |
| University of Texas at Austin | public educational institution of the United States, public research university | Austin | 1883 |
| University of Texas Medical Branch | hospital, public educational institution of the United States, research institute, medical school | — | 1891 |
| University of Texas Press | university press | Austin | 1950 |
| University of Texas Southwestern Medical Center | public educational institution of the United States, medical organization, medical school | — | 1943 |
| University of Texas System | state university system | Austin | 1876 |
| University of the Incarnate Word | private not-for-profit educational institution, university | — | 1881 |
| University of Tulsa | private not-for-profit educational institution, university, academic publisher | — | 1894 |
| University of Vermont | public educational institution of the United States, open-access publisher, land-grant university, public research university | Burlington | 1791 |
| University of Virginia | public educational institution of the United States, public research university | Charlottesville | January 25, 1819 |
| University of Virginia School of Law | law school, faculty | — | 1819 |
| University of West Georgia | public educational institution of the United States, university | — | 1906 |
| University of Wisconsin Press | university press | Madison | 1936 |
| University of Wisconsin System | state university system | Madison | 1848 |
| University of Wisconsin–Green Bay | public university | — | 1965 |
| University of Wisconsin–La Crosse | public educational institution of the United States, public university | — | 1909 |
| University of Wisconsin–Madison | public educational institution of the United States, land-grant university, public research university | — | 1848 |
| University of Wisconsin–Milwaukee | research university, public educational institution of the United States, public university | Milwaukee | 1885 |
| University of Wisconsin–Stevens Point | public educational institution of the United States, university, public university | Stevens Point | 1894 |
| University of Wyoming | public educational institution of the United States, land-grant university, public university | — | March 1886 |
| University System of Maryland | state university system | Baltimore | 1988 |
| UPA | film production company | Burbank | 1944 |
| UPS Airlines | cargo airline | Louisville | 1988 |
| US Airways | airline | Tempe | 1937 |
| US Airways Express | airline | Tempe | 1967 |
| US Foods | business, public company | Rosemont | August 1, 1989 |
| USA Today Co. | business, enterprise | Tysons, New York City | October 6, 1906 |
| USAA | insurance company, bank, business, financial institution | — | 1922 |
| USC School of Cinematic Arts | faculty, film school | — | 1929 |
| Ushahidi Inc. | nonprofit organization, technology company | Nairobi | January 9, 2008 |
| Valero Energy | business, gas station chain, enterprise, public company | — | 1980 |