| Washburn Guitars | trademark, musical instrument manufacturing company, subsidiary company | Chicago | 1883 |
| Washburn University | public educational institution of the United States, public university | — | 1865 |
| Washington Open | annual event, recurring tennis tournament, business | — | 1969 |
| Washington University in St. Louis | private not-for-profit educational institution, private university | St. Louis, St. Louis County | 1853 |
| Waste Management, Inc | business, public company | Houston | 1968 |
| Watch Tower Bible and Tract Society of Pennsylvania | nonprofit organization, real estate company, publishing house | Warwick | 1884 |
| Waterman | business | Paris | 1883 |
| Waters Corporation | business, enterprise | Milford | 1958 |
| WB Games Boston | video game developer | Westwood | 1994 |
| WCBS-TV | production company, television station | New York City | July 1, 1941 |
| Weatherby | business | Sheridan, Paso Robles | 1945 |
| Weber State University | public educational institution of the United States, campus university | — | 1889 |
| Webex by Cisco | business | Milpitas | 1995 |
| Wellesley College | private not-for-profit educational institution, women's college, university | — | 1870 |
| Wells Fargo | global systemically important bank, bank, business, financial institution, enterprise, public company | San Francisco | March 18, 1852 |
| Wesleyan University | private not-for-profit educational institution, private university | — | 1831 |
| West Virginia University | public educational institution of the United States, open-access publisher, land-grant university, public research university | Morgantown | 1867 |
| Western Digital | business, enterprise, public company | San Jose | April 23, 1970 |
| Western Global Airlines | airline | Estero | March 6, 2013 |
| Western Kentucky University | public educational institution of the United States, university | — | 1906 |
| Western Pacific Railroad | business, transport company | San Francisco | 1916 |
| Westwood Studios | video game developer, business | Las Vegas | 1992 |
| WeWork | real estate company, business, public company | Manhattan, New York | 2010 |
| Wexner Center for the Arts | art gallery, art museum, movie theater | — | 1989 |
| Weyerhaeuser | business, enterprise, public company | Seattle, Federal Way | 1900 |
| Whataburger | fast food restaurant chain | — | 1950 |
| Whirlpool Corporation | business, enterprise | Benton Harbor | November 11, 1911 |
| White Castle | fast food restaurant chain | Columbus | 1921 |
| White Motor Company | business, automobile manufacturer | Cleveland | 1902 |
| White Sands Test Facility | rocket engine test facility | — | 1963 |
| White Wolf Publishing | tabletop role-playing game publisher, publishing house, board game publishing company, business, enterprise | Stone Mountain | December 1990 |
| WHOOP | business | Boston | — |
| Wichita State University | public educational institution of the United States, university | — | 1886 |
| Wicked Pictures | pornography company, pornographic film studio | Canoga Park | 1993 |
| Wienerschnitzel | fast food restaurant chain | Irvine | 1961 |
| Wildfire Games | video game developer, enterprise | United States | 2002 |
| Wiley | book publisher, publishing house, educational publishing company, open-access publisher, public company, academic publisher | Hoboken | 1807 |
| Wiley-Blackwell | book publisher, publishing house, academic publisher | Hoboken | 2001 |
| Wilhelmina Models | modeling agency, public company | New York City | 1967 |
| Willard InterContinental Washington | tower block, hotel | — | 1847 |
| William B. Eerdmans Publishing Company | book publisher, business | Grand Rapids | 1911 |
| William Paterson University | public educational institution of the United States, university | — | 1855 |
| Wilson Sporting Goods | sporting goods manufacturer, organization, business | Chicago | 1913 |
| Winchester Repeating Arms Company | business, enterprise | New Haven | 1866 |
| Wind River Systems | business, enterprise | Alameda, California | 1981 |
| Windows on the World | restaurant | — | 1976 |
| Wingstop | fast food restaurant chain, business, public company | Dallas | 1994 |
| Winnebago Industries | business, enterprise, public company | Eden Prairie | February 12, 1958 |