| Winona State University | public educational institution of the United States, university | — | 1858 |
| Winton Motor Carriage Company | business, automobile manufacturer | Cleveland | 1897 |
| Wish.com | online marketplace, business, mobile app, enterprise | San Francisco | 2010 |
| WME Group | record label, business, talent agency, public company | Beverly Hills | 1898 |
| Woods Hole Oceanographic Institution | nonprofit organization, educational institution, research institute | Woods Hole | 1930 |
| Woot | business | Carrollton | 2004 |
| Workhorse Group | original equipment manufacturer, business, public company | Cincinnati, Sharonville | 1998 |
| World Airways | airline | Peachtree City | March 29, 1948 |
| World Bank | international financial institution, development bank | World Bank Headquarters | December 27, 1945 |
| World Championship Wrestling | privately held company, business, subsidiary company | Atlanta | October 11, 1988 |
| World Class Championship Wrestling | business | Dallas | 1966 |
| World Film Company | film production company | Fort Lee | 1914 |
| World of Wonder | film production company | Hollywood | 1991 |
| World Woman's Christian Temperance Union | production company, women's organization, non-governmental organization, Christian organization | Illinois, United States, Evanston | December 23, 1873 |
| Wrangler | business, subsidiary company | Greensboro | 1904 |
| Wright State University | public educational institution of the United States, public research university | — | 1964 |
| Wrigley Company | business | Chicago | April 1, 1891 |
| Wrike Inc. | business | Mountain View | 2006 |
| WSP Global | business, public company | Montreal | 1959 |
| WW International | business, enterprise, public company | New York City | 1963 |
| WWE | business, professional wrestling promotion, public company | Stamford | 1952 |
| WWE Performance Center | gym, professional wrestling school, business | Orlando | July 11, 2013 |
| Wynn Resorts | organization, business, enterprise, public company | Las Vegas | 2002 |
| X Corp. | privately held company, technology company, business | Bastrop | March 9, 2023 |
| XCOR Aerospace | business | Mojave Air and Space Port at Rutan Field | September 1999 |
| XFX | business | Ontario, California | 1989 |
| Ximian | business, enterprise | Boston | October 19, 1999 |
| XPO, Inc. | logistics company, business, enterprise, public company | Greenwich | 1987 |
| Yacht Club Games | video game developer | Valencia | 2011 |
| Yahoo Inc. | division, business, new media, company | Sunnyvale, New York City | 2006 |
| Yale Law School | law school, academic publisher | New Haven | 1824 |
| Yale School of Drama | drama school | — | 1924 |
| Yale University Press | book publisher, university press | New Haven | 1908 |
| Yelp | review site, social networking service, business, enterprise, public company | 140 New Montgomery, San Francisco | 2004 |
| Yerba Buena Center for the Arts | nonprofit organization, museum, movie theater, built structure | San Francisco | — |
| Yeshiva University | private not-for-profit educational institution, private university | New York City | 1886 |
| Young & Rubicam | advertising agency | Philadelphia, New York City | 1923 |
| Yum! Brands | corporation, group of companies, public company | Louisville | 1997 |
| Zaytuna College | college, seminary, university | — | 2008 |
| Zello | business | New York, Austin | — |
| Zendesk | software company, technology company, business, public company | San Francisco | 2007 |
| ZeniMax Online Studios | video game developer | Hunt Valley | 2007 |
| Zenith Electronics | organization, business, enterprise | — | 1918 |
| Zero Tolerance | film production company, pornographic film studio | Los Angeles | 2002 |
| Zillow | website, business, online real estate database, enterprise, public company | Seattle | 2006 |
| Zilog | business, enterprise | San Jose | 1974 |
| Zimmer Biomet Holdings | business, enterprise, public company | Warsaw | 1927 |
| Zippo | privately held company | Bradford | 1932 |